Yuji Itadori is the main protagonist of the Jujutsu Kaisen series. He is the son of Jin Itadori and grandson of Wasuke Itadori who was living a normal life until he encountered Megumi and ate one of Sukuna's fingers. After becoming Sukuna's vessel, Yuji began attending Tokyo Jujutsu High.

Megumi Fushiguro is the deuteragonist of the Jujutsu Kaisen series. Megumi entered Jujutsu High as a Grade 2 sorcerer and is considered to have high potential. Megumi inherited the Ten Shadows Technique, which is an inherited technique that ispassed down in the Zenin Family.

Nobara Kugisaki is the tritagonist of the Jujutsu Kaisen series. She is a first-year student and grade 3 jujutsu sorcerer at Tokyo Jujutsu High. Nobara employs the straw doll technique. Her technique involves utilizing jujutsu through a set of tools, which include a hammer, nails, and a straw doll.

Maki Zenin is a major supporting character in Jujutsu Kaisen. She is currently a second-year at Tokyo Jujutsu High. Maki was born as a non-sorcerer to one of the Big Three Sorcerer Clans, the Zenin Clan. As a result of being born a non-sorcerer Maki was constantly mistreated by her family.

Toge Inumaki is a descendant of the Inumaki clan who inherited the rare and powerful cursed speech technique. This prevents Toge from speaking normally so he's developed his own unique speech pattern to avoid cursing others. Toge is a semi-grade 1 jujutsu sorcerer and second-year at Tokyo Jujutsu High along with Yuta, Maki, and Panda.

Panda is not actually a panda, he's an Abrupt Mutated Cursed Corpse, the most advanced of his kind. Panda is a grade 2 sorcerer who was created by Masamichi Yaga. Panda is currently a second-year student at Jujutsu High. Due to Panda's natural affinity for jujutsu he is capable of exorcising curses based solely on his physical abilities.

Yuta Okkotsu is a major supporting character in the Jujutsu Kaisen series and the main protagonist of it's prequel series, Jujutsu Kaisen 0: Jujutsu High. He was initially a special grade cursed human haunted by his late childhood friend, Rika Orimoto. Yuta is one of only four special grade sorcerers recognized by Jujutsu High.

Aoi Todo is a supporting character in the Jujutsu Kaisen series. He is a third-year student at Kyoto Jujutsu High School and a grade 1 jujutsu sorcerer. Aoi is an exceptionally powerful sorcerer, undoubtedly one of Jujutsu High's strongest students. He obtained the rank of a grade 1 jujutsu sorcerer as a student despite coming from a non-sorcerer family.

Mai Zenin is a character in the Jujutsu Kaisen series. She was a second-year at student at Kyoto Jujutsu High, member of the Zenin clan, and the younger twin sister of Maki Zenin. Mai possesses above average cursed energy for a human but less than the normal sorcerer.However, she nor Maki were able to gain an Inherited Technique of the Zenin clan.

Noritoshi Kamo is a third-year at Kyoto Metropolitan Curse Technical College and heir to the head of the Kamo clan. Noritoshi is a semi-grade 1 sorcerer with the ability to use the Kamo Family's acclaimed Inherited Technique: Blood Manipulation. He is a skilled marksman who incorporates jujutsu into his archery.

Kokichi Muta is a second-year at Kyoto Jujutsu High using Ultimate Mechamaru as his proxy to attend school. Kokichi himself could not due to the sickly and fragile body he was born with as a result of his Heavenly Restriction. As a result of his Heavenly Restriction, Kokichi's cursed energy was vast enough to cover the entire nation of Japan.

Momo Nishimiya is a character in the Jujutsu Kaisen series. She is a third-year student at Kyoto Jujutsu High and a semi-grade 2 jujutsu sorcerer. Momo uses an innate technique called tool manipulation. She can telepathically control her broom, allowing her to levitate it independently of herself.

Kasumi Miwa is a second-year at Kyoto Jujutsu High. Kasumi was born in Tokyo, coming from a poor family with two younger brothers. In Junior High, she met a mentor who would allow her to become a jujutsu sorcerer. Although she had never held a sword before, she trained so that she wouldn't be a burden to her mother.